Plasma undercarboxylated osteocalcin dynamics with glycemic stress reflects insulin sensitivity and beta-cell function in humans with and without T2DM

Plasma undercarboxylated osteocalcin dynamics with glycemic stress reflects insulin sensitivity and beta-cell function in humans with and without T2DM

This study aimed to better understand the relationship between bone-related biomarkers and nutrient stress in the context of metabolic health. We investigated plasma osteocalcin (OC) during an oral glucose challenge and experimental hyperinsulinemia in Type 2 diabetes (T2DM) and lean healthy control...

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Bibliographic Details
Main Authors: Kelly N.Z. Fuller, Erin M. Bohne, Jacob T. Mey, Brian K. Blackburn, Victoria R. Miranda, Krista A. Varady, Kirstie K. Danielson, Jacob M. Haus
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Metabolism Open
Subjects:
Adipokines
Alkaline phosphatase
Hyperinsulinemia-euglycemic clamp
OGTT
Bone
Online Access:http://www.sciencedirect.com/science/article/pii/S2589936823000361

Internet

http://www.sciencedirect.com/science/article/pii/S2589936823000361

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