Exosomal miR-335 derived from mature dendritic cells enhanced mesenchymal stem cell-mediated bone regeneration of bone defects in athymic rats

Exosomal miR-335 derived from mature dendritic cells enhanced mesenchymal stem cell-mediated bone regeneration of bone defects in athymic rats

Abstract Background Transplantation of bone marrow-derived mesenchymal stem cells (BM-MSCs) embedded in a bio-compatible matrix has been demonstrated as a promising strategy for the treatment of bone defects. This study was designed to explore the effect and mechanism of exosomes derived from mature...

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Bibliographic Details
Main Authors: Zhongliu Cao, Yanfeng Wu, Lingling Yu, Lingfeng Zou, Liu Yang, Sijian Lin, Jue Wang, Zhen Yuan, Jianghua Dai
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Molecular Medicine
Subjects:
Mesenchymal stem cells
Dendritic cell
Exosome
miR-335
Bone defect
Online Access:https://doi.org/10.1186/s10020-021-00268-5

Internet

https://doi.org/10.1186/s10020-021-00268-5

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