Interplay Between Chemotherapy-Activated Cancer Associated Fibroblasts and Cancer Initiating Cells Expressing CD44v6 Promotes Colon Cancer Resistance

Interplay Between Chemotherapy-Activated Cancer Associated Fibroblasts and Cancer Initiating Cells Expressing CD44v6 Promotes Colon Cancer Resistance

Cancer-initiating cells (CICs) drive colorectal tumor growth by their supportive niches where CICs interact with multiple cell types within the microenvironment, including cancer-associated fibroblasts (CAFs). We investigated the interplay between the CICs and the clinically relevant chemotherapeuti...

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Bibliographic Details
Main Authors: Shibnath Ghatak, Vincent C. Hascall, Nikos Karamanos, Roger R. Markwald, Suniti Misra
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Oncology
Subjects:
colorectal cancer (CRC)
cancer initiating cells (CICs)
cancer associate fibroblasts (CAFs)
CD44v6
periostin
IL17A
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.906415/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.906415/full

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