Dietary intake of fatty acids and risk of pancreatic cancer: Golestan cohort study
Abstract Background As pancreatic cancer (PC) is a malignancy with poor prognosis, finding strategies for its prevention became a notable priority. Among all the factors influencing the risk of PC, dietary items especially fats are considered as the most modifiable risk factors.This study is designe...
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| Format: | Article |
| Language: | English |
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BMC
2021-07-01
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| Series: | Nutrition Journal |
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| Online Access: | https://doi.org/10.1186/s12937-021-00723-3 |
| _version_ | 1819154852280795136 |
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| author | Neda Ghamarzad Shishavan Sahar Masoudi Ashraf Mohamadkhani Sadaf G. Sepanlou Maryam Sharafkhah Hossein Poustchi Mehdi Mohamadnejad Azita Hekmatdoost Akram Pourshams |
| author_facet | Neda Ghamarzad Shishavan Sahar Masoudi Ashraf Mohamadkhani Sadaf G. Sepanlou Maryam Sharafkhah Hossein Poustchi Mehdi Mohamadnejad Azita Hekmatdoost Akram Pourshams |
| author_sort | Neda Ghamarzad Shishavan |
| collection | DOAJ |
| description | Abstract Background As pancreatic cancer (PC) is a malignancy with poor prognosis, finding strategies for its prevention became a notable priority. Among all the factors influencing the risk of PC, dietary items especially fats are considered as the most modifiable risk factors.This study is designed to assess the associations of dietary intake of fatty acids with the risk of PC incidence. Methods A total of 50,045 adults between 40 and 75 years old participated in this cohort study in 2004–2008 and were followed up to the present. Intakes of fatty acids was evaluated by validated food-frequency questionnaire (FFQ). Cox proportional hazards regression model was used to estimate hazard ratio (HR) with 95 % confidence interval of differing levels of dietary intakes of fatty acids for incidence of PC. Results At the end of follow-up period, 76 cases of PC were identified and 46,904 participants without history of cancer, acute kidney disorders, fibrosis and cirrhosis were included in the study. Dietary total saturated fatty acids (SFAS) was associated with PC risk (HR = 1.05 (1.01–1.09), Ptrend=0.01), whereas dietary total monounsaturated fatty acids (MUFAS) was inversely associated with the risk of PC (HR = 0.92 (0.86–0.99), Ptrend=0.04). Dietary total polyunsaturated fatty acids (PUFAS) did show a protective but not significant association with the risk of PC (HR = 0.91(0.84-1.00), Ptrend=0.05). Conclusions The amount of total fat intake is not a risk factor for PC in our study and focusing on the intake of specific fatty acids becomes more striking. Unsaturated fatty acids including PUFAS and especially MUFAS are considered as protective dietary factors in PC prevention. In contrast, total SFAS is positively associated with the increased risk of PC. However, very long chain and odd-chain saturated fatty acids intake may be protective against PC. |
| first_indexed | 2024-12-22T15:27:40Z |
| format | Article |
| id | doaj.art-4d0659cc55754453bbe23386ba9d242c |
| institution | Directory Open Access Journal |
| issn | 1475-2891 |
| language | English |
| last_indexed | 2024-12-22T15:27:40Z |
| publishDate | 2021-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Nutrition Journal |
| spelling | doaj.art-4d0659cc55754453bbe23386ba9d242c2022-12-21T18:21:27ZengBMCNutrition Journal1475-28912021-07-0120111410.1186/s12937-021-00723-3Dietary intake of fatty acids and risk of pancreatic cancer: Golestan cohort studyNeda Ghamarzad Shishavan0Sahar Masoudi1Ashraf Mohamadkhani2Sadaf G. Sepanlou3Maryam Sharafkhah4Hossein Poustchi5Mehdi Mohamadnejad6Azita Hekmatdoost7Akram Pourshams8Digestive Oncology Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical SciencesDigestive Oncology Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical SciencesLiver and Pancreatobiliary Diseases Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical SciencesDigestive Oncology Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical SciencesDigestive Oncology Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical SciencesLiver and Pancreatobiliary Diseases Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical SciencesDigestive Oncology Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical SciencesDepartments of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical SciencesDigestive Oncology Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical SciencesAbstract Background As pancreatic cancer (PC) is a malignancy with poor prognosis, finding strategies for its prevention became a notable priority. Among all the factors influencing the risk of PC, dietary items especially fats are considered as the most modifiable risk factors.This study is designed to assess the associations of dietary intake of fatty acids with the risk of PC incidence. Methods A total of 50,045 adults between 40 and 75 years old participated in this cohort study in 2004–2008 and were followed up to the present. Intakes of fatty acids was evaluated by validated food-frequency questionnaire (FFQ). Cox proportional hazards regression model was used to estimate hazard ratio (HR) with 95 % confidence interval of differing levels of dietary intakes of fatty acids for incidence of PC. Results At the end of follow-up period, 76 cases of PC were identified and 46,904 participants without history of cancer, acute kidney disorders, fibrosis and cirrhosis were included in the study. Dietary total saturated fatty acids (SFAS) was associated with PC risk (HR = 1.05 (1.01–1.09), Ptrend=0.01), whereas dietary total monounsaturated fatty acids (MUFAS) was inversely associated with the risk of PC (HR = 0.92 (0.86–0.99), Ptrend=0.04). Dietary total polyunsaturated fatty acids (PUFAS) did show a protective but not significant association with the risk of PC (HR = 0.91(0.84-1.00), Ptrend=0.05). Conclusions The amount of total fat intake is not a risk factor for PC in our study and focusing on the intake of specific fatty acids becomes more striking. Unsaturated fatty acids including PUFAS and especially MUFAS are considered as protective dietary factors in PC prevention. In contrast, total SFAS is positively associated with the increased risk of PC. However, very long chain and odd-chain saturated fatty acids intake may be protective against PC.https://doi.org/10.1186/s12937-021-00723-3Pancreatic cancerFatty acidDietary intakeDietary fatGolestan Cohort Study |
| spellingShingle | Neda Ghamarzad Shishavan Sahar Masoudi Ashraf Mohamadkhani Sadaf G. Sepanlou Maryam Sharafkhah Hossein Poustchi Mehdi Mohamadnejad Azita Hekmatdoost Akram Pourshams Dietary intake of fatty acids and risk of pancreatic cancer: Golestan cohort study Nutrition Journal Pancreatic cancer Fatty acid Dietary intake Dietary fat Golestan Cohort Study |
| title | Dietary intake of fatty acids and risk of pancreatic cancer: Golestan cohort study |
| title_full | Dietary intake of fatty acids and risk of pancreatic cancer: Golestan cohort study |
| title_fullStr | Dietary intake of fatty acids and risk of pancreatic cancer: Golestan cohort study |
| title_full_unstemmed | Dietary intake of fatty acids and risk of pancreatic cancer: Golestan cohort study |
| title_short | Dietary intake of fatty acids and risk of pancreatic cancer: Golestan cohort study |
| title_sort | dietary intake of fatty acids and risk of pancreatic cancer golestan cohort study |
| topic | Pancreatic cancer Fatty acid Dietary intake Dietary fat Golestan Cohort Study |
| url | https://doi.org/10.1186/s12937-021-00723-3 |
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