Methods for quantitative susceptibility and R2* mapping in whole post-mortem brains at 7T applied to amyotrophic lateral sclerosis

Methods for quantitative susceptibility and R2* mapping in whole post-mortem brains at 7T applied to amyotrophic lateral sclerosis

Susceptibility weighted magnetic resonance imaging (MRI) is sensitive to the local concentration of iron and myelin. Here, we describe a robust image processing pipeline for quantitative susceptibility mapping (QSM) and R2* mapping of fixed post-mortem, whole-brain data. Using this pipeline, we comp...

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Bibliographic Details
Main Authors: Chaoyue Wang, Sean Foxley, Olaf Ansorge, Sarah Bangerter-Christensen, Mark Chiew, Anna Leonte, Ricarda AL Menke, Jeroen Mollink, Menuka Pallebage-Gamarallage, Martin R Turner, Karla L Miller, Benjamin C. Tendler
Format: Article
Language:English
Published: Elsevier 2020-11-01
Series:NeuroImage
Subjects:
Quantitative susceptibility mapping
R2* mapping
Post-mortem
Amyotrophic lateral sclerosis
Ferritin
Myelin
Online Access:http://www.sciencedirect.com/science/article/pii/S1053811920307023

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http://www.sciencedirect.com/science/article/pii/S1053811920307023

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