Poliovirus trafficking toward central nervous system via human poliovirus receptor-dependent and -independent pathway.
In humans, paralytic poliomyelitis results from the invasion of the central nervous system by circulating poliovirus (PV) via the blood-brain barrier (BBB). After the virus enters the central nervous system (CNS), it replicates in neurons, especially in motor neurons (MNs), inducing the cell death...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2012-04-01
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| Series: | Frontiers in Microbiology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fmicb.2012.00147/full |