Deconvolution of synovial myeloid cell subsets across pathotypes and role of COL3A1+ macrophages in rheumatoid arthritis remission

Deconvolution of synovial myeloid cell subsets across pathotypes and role of COL3A1+ macrophages in rheumatoid arthritis remission

BackgroundMonocyte/macrophage (Mo/Mp) is a critical cell population involved in immune modulation of rheumatoid synovitis (RA) across different pathotypes. This study aims to investigate the contribution of Mo/Mp clusters to RA activity, and the biological function of particular subtypes in RA remis...

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Bibliographic Details
Main Authors: Xuantao Hu, Ziji Zhang, Lingli Long, Minghu Gu, Weishen Chen, Baiqi Pan, Xiaoyu Wu, Chao Wang, Chengxin Li, Linli Zheng, Puyi Sheng
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Immunology
Subjects:
rheumatoid arthritis
single-cell RNA sequencing
myeloid cell
gene deconvolution
macrophage-myofibroblast transition
immunosuppression
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1307748/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1307748/full

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