Evodiamine-inspired dual inhibitors of histone deacetylase 1 (HDAC1) and topoisomerase 2 (TOP2) with potent antitumor activity

Evodiamine-inspired dual inhibitors of histone deacetylase 1 (HDAC1) and topoisomerase 2 (TOP2) with potent antitumor activity

A great challenge in multi-targeting drug discovery is to identify drug-like lead compounds with therapeutic advantages over single target inhibitors and drug combinations. Inspired by our previous efforts in designing antitumor evodiamine derivatives, herein selective histone deacetylase 1 (HDAC1)...

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Bibliographic Details
Main Authors: Yahui Huang, Shuqiang Chen, Shanchao Wu, Guoqiang Dong, Chunquan Sheng
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Evodiamine
Histone deacetylase
Topoisomerase
Dual inhibitors
Antitumor activity
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383519310160

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http://www.sciencedirect.com/science/article/pii/S2211383519310160

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