Detection of APP gene recombinant in human blood plasma

Abstract The pathogenesis of Alzheimer’s disease (AD) is believed to involve the accumulation of amyloid-β in the brain, which is produced by the sequential cleavage of amyloid precursor protein (APP) by β-secretase and γ-secretase. Recently, analysis of genomic DNA and mRNA from postmortem brain ne...

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Bibliographic Details
Main Authors: Shigeki Mitsunaga, Naoko Fujito, Hirofumi Nakaoka, Ryoko Imazeki, Eiichiro Nagata, Ituro Inoue
Format: Article
Language:English
Published: Nature Portfolio 2023-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-48993-7