Use of viral motif mimicry improves the proteome-wide discovery of human linear motifs

Summary: Linear motifs have an integral role in dynamic cell functions, including cell signaling. However, due to their small size, low complexity, and frequent mutations, identifying novel functional motifs poses a challenge. Viruses rely extensively on the molecular mimicry of cellular linear moti...

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Hlavní autoři: Bishoy Wadie, Vitalii Kleshchevnikov, Elissavet Sandaltzopoulou, Caroline Benz, Evangelia Petsalaki
Médium: Článek
Jazyk:English
Vydáno: Elsevier 2022-05-01
Edice:Cell Reports
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On-line přístup:http://www.sciencedirect.com/science/article/pii/S2211124722005289