Searching for Frataxin Function: Exploring the Analogy with Nqo15, the Frataxin-like Protein of Respiratory Complex I from <i>Thermus thermophilus</i>
Nqo15 is a subunit of respiratory complex I of the bacterium <i>Thermus thermophilus</i>, with strong structural similarity to human frataxin (FXN), a protein involved in the mitochondrial disease Friedreich’s ataxia (FRDA). Recently, we showed that the expression of recombinant Nqo15 ca...
Main Authors: | Davide Doni, Eva Cavallari, Martin Ezequiel Noguera, Hernan Gustavo Gentili, Federica Cavion, Gustavo Parisi, Maria Silvina Fornasari, Geppo Sartori, Javier Santos, Massimo Bellanda, Donatella Carbonera, Paola Costantini, Marco Bortolus |
---|---|
Format: | Article |
Language: | English |
Published: |
MDPI AG
2024-02-01
|
Series: | International Journal of Molecular Sciences |
Subjects: | |
Online Access: | https://www.mdpi.com/1422-0067/25/3/1912 |
Similar Items
-
A Combined Spectroscopic and In Silico Approach to Evaluate the Interaction of Human Frataxin with Mitochondrial Superoxide Dismutase
by: Davide Doni, et al.
Published: (2021-11-01) -
Neurobehavioral deficits of mice expressing a low level of G127V mutant frataxin
by: Daniel Fil, et al.
Published: (2023-02-01) -
Frataxin deficiency alters gene expression in Friedreich ataxia derived IPSC‐neurons and cardiomyocytes
by: Mariana B. Angulo, et al.
Published: (2023-01-01) -
Adding a temporal dimension to the study of Friedreich's ataxia: the effect of frataxin overexpression in a human cell model
by: Tommaso Vannocci, et al.
Published: (2018-06-01) -
Frataxin deficiency unveils cell-context dependent actions of insulin-like growth factor I on neurons
by: Franco Carolina, et al.
Published: (2012-10-01)