Activation of eIF4E‐binding‐protein‐1 rescues mTORC1‐induced sarcopenia by expanding lysosomal degradation capacity

Activation of eIF4E‐binding‐protein‐1 rescues mTORC1‐induced sarcopenia by expanding lysosomal degradation capacity

Abstract Background Chronic mTORC1 activation in skeletal muscle is linked with age‐associated loss of muscle mass and strength, known as sarcopenia. Genetic activation of mTORC1 by conditionally ablating mTORC1 upstream inhibitor TSC1 in skeletal muscle accelerates sarcopenia development in adult m...

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Bibliographic Details
Main Authors: Elisa M. Crombie, Seonyoung Kim, Stuart Adamson, Han Dong, Tzu‐Chiao Lu, Yiju Wu, Yajun Wu, Yotam Levy, Nolan Stimple, Wing Moon R. Lam, Hwee Weng D. Hey, Dominic J. Withers, Ao‐Lin Hsu, Boon Huat Bay, Julien Ochala, Shih‐Yin Tsai
Format: Article
Language:English
Published: Wiley 2023-02-01
Series:Journal of Cachexia, Sarcopenia and Muscle
Subjects:
mitochondrial dysfunction
mRNA translation
mTORC1
protein degradation
sarcopenia
Online Access:https://doi.org/10.1002/jcsm.13121

Internet

https://doi.org/10.1002/jcsm.13121

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