Involvement of large-conductance Ca2+-activated K+ channels in chloroquine-induced force alterations in pre-contracted airway smooth muscle.

Involvement of large-conductance Ca2+-activated K+ channels in chloroquine-induced force alterations in pre-contracted airway smooth muscle.

The participation of large-conductance Ca2+ activated K+ channels (BKs) in chloroquine (chloro)-induced relaxation of precontracted airway smooth muscle (ASM) is currently undefined. In this study we found that iberiotoxin (IbTx, a selective inhibitor of BKs) and chloro both completely blocked spont...

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Bibliographic Details
Main Authors: Ming-Yu Wei, Lu Xue, Li Tan, Wen-Bo Sai, Xiao-Cao Liu, Qiu-Ju Jiang, Jinhua Shen, Yong-Bo Peng, Ping Zhao, Meng-Fei Yu, Weiwei Chen, Li-Qun Ma, Kui Zhai, Chunbin Zou, Donglin Guo, Gangjian Qin, Yun-Min Zheng, Yong-Xiao Wang, Guangju Ji, Qing-Hua Liu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4378962?pdf=render

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http://europepmc.org/articles/PMC4378962?pdf=render

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