Development of Thiazolidinones as Fungal Carbonic Anhydrase Inhibitors

Development of Thiazolidinones as Fungal Carbonic Anhydrase Inhibitors

In our efforts to find new and selective thiazolidinone-based anti-<i>Candida</i> agents, we synthesized and tested 26 thiazolidinones against several <i>Candida</i> spp. and Gram-positive and Gram-negative bacteria. The compounds showed selective antifungal activity with pot...

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Bibliographic Details
Main Authors: Özlen Güzel-Akdemir, Simone Carradori, Rossella Grande, Kübra Demir-Yazıcı, Andrea Angeli, Claudiu T. Supuran, Atilla Akdemir
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:International Journal of Molecular Sciences
Subjects:
4-thiazolidinones
antifungal activity
molecular modelling studies
carbonic anhydrases
lanosterol 14α-demethylase
CYP51a1
Online Access:https://www.mdpi.com/1422-0067/21/8/2960

Internet

https://www.mdpi.com/1422-0067/21/8/2960

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