Efficient adeno-associated virus serotype 5 capture with affinity functionalized nanofiber adsorbents

Efficient adeno-associated virus serotype 5 capture with affinity functionalized nanofiber adsorbents

Adeno-associated viruses (AAVs) are one of the most promising tools for gene therapy applications. These vectors are purified using affinity and ion exchange chromatography, typically using packed beds of resin adsorbents. This leads to diffusion and pressure drop limitations that affect process pro...

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Bibliographic Details
Main Authors: Salomé Neto, João P. Mendes, Susana B. Dos Santos, Anita Solbrand, Manuel J. T. Carrondo, Cristina Peixoto, Ricardo J. S. Silva
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
AAV5
affinity chromatography
gene therapy
non-woven materials
cellulose-based nanofibers
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2023.1183974/full

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https://www.frontiersin.org/articles/10.3389/fbioe.2023.1183974/full

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