Synthesis and Biological Evaluation of Novel <i>Dispiro</i>-Indolinones with Anticancer Activity

Synthesis and Biological Evaluation of Novel <i>Dispiro</i>-Indolinones with Anticancer Activity

Novel variously substituted thiohydantoin-based <i>dispiro</i>-indolinones were prepared using a regio- and diastereoselective synthetic route from 5-arylidene-2-thiohydantoins, isatines, and sarcosine. The obtained molecules were subsequently evaluated in vitro against the cancer cell l...

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Bibliographic Details
Main Authors: Yan A. Ivanenkov, Maxim E. Kukushkin, Anastasia A. Beloglazkina, Radik R. Shafikov, Alexander A. Barashkin, Andrey A. Ayginin, Marina S. Serebryakova, Alexander G. Majouga, Dmitry A. Skvortsov, Viktor A. Tafeenko, Elena K. Beloglazkina
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Molecules
Subjects:
<i>dispiro</i>-indolinones
MDM2
p53
PPI
molecular docking
cytotoxicity
Online Access:https://www.mdpi.com/1420-3049/28/3/1325

Internet

https://www.mdpi.com/1420-3049/28/3/1325

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