Hypoxia within subcutaneously implanted macroencapsulation devices limits the viability and functionality of densely loaded islets

Hypoxia within subcutaneously implanted macroencapsulation devices limits the viability and functionality of densely loaded islets

IntroductionSubcutaneous macroencapsulation devices circumvent disadvantages of intraportal islet therapy. However, a curative dose of islets within reasonably sized devices requires dense cell packing. We measured internal PO2 of implanted devices, mathematically modeled oxygen availability within...

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Bibliographic Details
Main Authors: Samuel A. Einstein, Leah V. Steyn, Bradley P. Weegman, Thomas M. Suszynski, Athanassios Sambanis, Timothy D. O’Brien, Efstathios S. Avgoustiniatos, Meri T. Firpo, Melanie L. Graham, Jody Janecek, Lynn E. Eberly, Michael Garwood, Charles W. Putnam, Klearchos K. Papas
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Transplantation
Subjects:
islet transplantation
immunoisolation
fluorine-19
magnetic resonance spectroscopy
tissue engineering
hypoxia
Online Access:https://www.frontiersin.org/articles/10.3389/frtra.2023.1257029/full

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https://www.frontiersin.org/articles/10.3389/frtra.2023.1257029/full

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