Borrelia burgdorferi initiates early transcriptional re-programming in macrophages that supports long-term suppression of inflammation.

Borrelia burgdorferi (Bb), the causative agent of Lyme disease, establishes a long-term infection and leads to disease manifestations that are the result of host immune responses to the pathogen. Inflammatory manifestations resolve spontaneously despite continued bacterial presence, suggesting infla...

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Bibliographic Details
Main Authors: Tanja Petnicki-Ocwieja, Julie E McCarthy, Urmila Powale, P Kent Langston, Jennifer D Helble, Linden T Hu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-12-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1011886