Inhibitory effect of truncated isoforms on GPCR dimerization predicted by combinatorial computational strategy

Inhibitory effect of truncated isoforms on GPCR dimerization predicted by combinatorial computational strategy

G protein-coupled receptors (GPCRs) play a pivotal role in fundamental biological processes and disease development. GPCR isoforms, derived from alternative splicing, can exhibit distinct signaling patterns. Some highly-truncated isoforms can impact functional performance of full-length receptors, s...

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Bibliographic Details
Main Authors: Mengke Li, Rui Qing, Fei Tao, Ping Xu, Shuguang Zhang
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Computational and Structural Biotechnology Journal
Subjects:
AlphaFold2 prediction
Complex structure prediction
GPCR oligomerization
Molecular docking
Transmembrane truncation
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037023004828

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