Differential Effect of Three Macrolide Antibiotics on Cardiac Pathology and Electrophysiology in a Myocardial Infarction Rat Model: Influence on Sodium Nav1.5 Channel Expression

Differential Effect of Three Macrolide Antibiotics on Cardiac Pathology and Electrophysiology in a Myocardial Infarction Rat Model: Influence on Sodium Nav1.5 Channel Expression

Macrolides were reported to have cardiotoxic effects presented mainly by electrocardiogram (ECG) changes with increased risk in cardiac patients. We aimed to determine the impact of three macrolides, azithromycin, clarithromycin and erythromycin, on cardiac electrophysiology, cardiac enzyme activiti...

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Bibliographic Details
Main Authors: Noha E. Farag, Mohamed K. El-Kherbetawy, Hussein M. Ismail, Ahmed M. Abdelrady, Eman A. Toraih, Walid Kamal Abdelbasset, Rehab M. Lashine, Mohammed EL-dosoky, Sally Yussef Abed, Khalid M. Ibraheem, Manal S. Fawzy, Sawsan A. Zaitone
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Pharmaceuticals
Subjects:
azithromycin
cardiotoxicity
clarithromycin
ECG
erythromycin
myocardial infarction rat model
Online Access:https://www.mdpi.com/1424-8247/14/7/597

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https://www.mdpi.com/1424-8247/14/7/597

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