A dominant negative ERβ splice variant determines the effectiveness of early or late estrogen therapy after ovariectomy in rats.

A dominant negative ERβ splice variant determines the effectiveness of early or late estrogen therapy after ovariectomy in rats.

The molecular mechanisms for the discrepancy in outcome of initiating estrogen therapy (ET) around peri-menopause or several years after menopause in women are unknown. We hypothesize that the level of expression of a dominant negative estrogen receptor (ER) β variant, ERβ2, may be a key factor dete...

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Bibliographic Details
Main Authors: Jun Ming Wang, Xu Hou, Samuel Adeosun, Rosanne Hill, Sherry Henry, Ian Paul, Ronald W Irwin, Xiao-Ming Ou, Steven Bigler, Craig Stockmeier, Roberta Diaz Brinton, Elise Gomez-Sanchez
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3302771?pdf=render

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http://europepmc.org/articles/PMC3302771?pdf=render

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