A SWATH-MS analysis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome peripheral blood mononuclear cell proteomes reveals mitochondrial dysfunction

A SWATH-MS analysis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome peripheral blood mononuclear cell proteomes reveals mitochondrial dysfunction

Abstract Background Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a serious and complex physical illness that affects all body systems with a multiplicity of symptoms, but key hallmarks of the disease are pervasive fatigue and ‘post-exertional malaise’, exacerbation after physical a...

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Bibliographic Details
Main Authors: Eiren Sweetman, Torsten Kleffmann, Christina Edgar, Michel de Lange, Rosamund Vallings, Warren Tate
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Journal of Translational Medicine
Subjects:
Myalgic encephalomyelitis
Chronic fatigue syndrome
Diagnostic biomarker
Mitochondria
Oxidative phosphorylation
Reactive oxygen species
Online Access:http://link.springer.com/article/10.1186/s12967-020-02533-3

Internet

http://link.springer.com/article/10.1186/s12967-020-02533-3

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