Role of mitochondria ROS generation in ethanol-induced NLRP3 inflammasome activation and cell death in astroglial cells

Role of mitochondria ROS generation in ethanol-induced NLRP3 inflammasome activation and cell death in astroglial cells

Toll-like receptors (TLRs) and Nod-like receptors (NLRs) are innate immunity sensors that provide an early/effective response to pathogenic or injury conditions. We have reported that ethanol-induced TLR4 activation triggers signaling inflammatory responses in glial cells, causing neuroinflammation...

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Bibliographic Details
Main Authors: Silvia eAlfonso-Loeches, Juan eUreña-Peralta, Maria Jose eMorillo Bargues, Jorge eOliver-De la Cruz, Consuelo eGUERRI
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-08-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Apoptosis
Astrocytes
Ethanol
TLR4
pyroptosis
ROS
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00216/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00216/full

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