The Accumulation of Tau-Immunoreactive Hippocampal Granules and Corpora Amylacea Implicates Reactive Glia in Tau Pathogenesis during Aging

The Accumulation of Tau-Immunoreactive Hippocampal Granules and Corpora Amylacea Implicates Reactive Glia in Tau Pathogenesis during Aging

Summary: The microtubule-associated tau protein forms pathological inclusions that accumulate in an age-dependent manner in tauopathies including Alzheimer's disease (AD). Since age is the major risk factor for AD, we examined endogenous tau species that evolve during aging in physiological and...

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Bibliographic Details
Main Authors: Connor M. Wander, Jui-Heng Tseng, Sheng Song, Heba A. Al Housseiny, Dalton S. Tart, Aditi Ajit, Yen-Yu Ian Shih, Rebecca Lobrovich, Juan Song, Rick B. Meeker, David J. Irwin, Todd J. Cohen
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:iScience
Subjects:
Neuroscience
Molecular Neuroscience
Cellular Neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220304417

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http://www.sciencedirect.com/science/article/pii/S2589004220304417

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