Complex molecular profile of DNA repair genes in epithelial ovarian carcinoma patients with different sensitivity to platinum-based therapy

Complex molecular profile of DNA repair genes in epithelial ovarian carcinoma patients with different sensitivity to platinum-based therapy

Epithelial ovarian carcinoma (EOC) is known for high mortality due to diagnosis at advanced stages and frequent therapy resistance. Previous findings suggested that the DNA repair system is involved in the therapeutic response of cancer patients and DNA repair genes are promising targets for novel t...

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Bibliographic Details
Main Authors: Karolina Seborova, Viktor Hlavac, Petr Holy, Sunniva S. Bjørklund, Thomas Fleischer, Lukas Rob, Martin Hruda, Jiri Bouda, Marcela Mrhalova, Mohammad Moufaq Khatar Al Obeed Allah, Pavel Vodicka, Ondrej Fiala, Pavel Soucek, Vessela N. Kristensen, Ludmila Vodickova, Radka Vaclavikova
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Oncology
Subjects:
ovarian carcinoma
DNA repair genes
resistance
transcriptome
methylome
whole exome sequencing
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.1016958/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.1016958/full

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