Discovery of Cyclic Peptide Inhibitors Targeted on TNFα-TNFR1 from Computational Design and Bioactivity Verification

Discovery of Cyclic Peptide Inhibitors Targeted on TNFα-TNFR1 from Computational Design and Bioactivity Verification

Activating tumor necrosis factor receptor 1 (TNFR1) with tumor necrosis factor alpha (TNFα) is one of the key pathological mechanisms resulting in the exacerbation of rheumatoid arthritis (RA) immune response. Despite various types of drugs being available for the treatment of RA, a series of shortc...

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Bibliographic Details
Main Authors: Jiangnan Zhang, Huijian Zhao, Qianqian Zhou, Xiaoyue Yang, Haoran Qi, Yongxing Zhao, Longhua Yang
Format: Article
Language:English
Published: MDPI AG 2024-10-01
Series:Molecules
Subjects:
molecular dynamics simulation
computational drug design
cyclic peptide
TNFα
TNFR1
Online Access:https://www.mdpi.com/1420-3049/29/21/5147

Internet

https://www.mdpi.com/1420-3049/29/21/5147

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