Microglia replacement by bone marrow transplantation (Mr BMT) in the central nervous system of adult mice

Summary: Microglia are important immune cells in the central nervous system (CNS). Mutations in microglia may cause CNS disorders. Replacement of dysfunctional microglia with allogeneic wild-type microglia can correct the gene deficiency, thus treating the neurogenic diseases. However, traditional a...

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Bibliographic Details
Main Authors: Zhen Xu, Xin Zhou, Bo Peng, Yanxia Rao
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:STAR Protocols
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2666166721003737