Chemoenzymatic Synthesis of Selegiline: An Imine Reductase-Catalyzed Approach

Chemoenzymatic Synthesis of Selegiline: An Imine Reductase-Catalyzed Approach

(<i>R</i>)-Homobenzylic amines are key structural motifs present in (<i>R</i>)-selegiline, a drug indicated for the treatment of early-stage Parkinson’s disease. Herein, we report a new short chemoenzymatic approach (in 2 steps) towards the synthesis of (<i>R</i>)...

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Bibliographic Details
Main Authors: Yuliang Hu, Jinping Bao, Dongyu Tang, Shushan Gao, Fei Wang, Zhongtao Ding, Chengsen Cui
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Molecules
Subjects:
imine reductase
reductive amination
semi-rational design
homobenzylic amine
chemoenzymatic synthesis
Online Access:https://www.mdpi.com/1420-3049/29/6/1328

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https://www.mdpi.com/1420-3049/29/6/1328

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