Role of allopregnanolone-mediated γ-aminobutyric acid A receptor sensitivity in the pathogenesis of premenstrual dysphoric disorder: Toward precise targets for translational medicine and drug development

Role of allopregnanolone-mediated γ-aminobutyric acid A receptor sensitivity in the pathogenesis of premenstrual dysphoric disorder: Toward precise targets for translational medicine and drug development

Premenstrual dysphoric disorder (PMDD) can be conceptualized as a disorder of suboptimal sensitivity to neuroactive steroid hormones. Its core symptoms (emotional instability, irritability, depression, and anxiety) are related to the increase of stress sensitivity due to the fluctuation of hormone l...

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Bibliographic Details
Main Authors: Qian Gao, Wei Sun, Yue-Rui Wang, Zi-Fa Li, Feng Zhao, Xi-Wen Geng, Kai-Yong Xu, Dan Chen, Kun Liu, Ying Xing, Wei Liu, Sheng Wei
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Psychiatry
Subjects:
premenstrual dysphoric disorder
premenstrual syndrome
pathogenesis
allopregnanolone
γ-aminobutyric acid A receptor
subunit
Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1140796/full

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https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1140796/full

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