GPR39 localization in the aging human brain and correlation of expression and polymorphism with vascular cognitive impairment

GPR39 localization in the aging human brain and correlation of expression and polymorphism with vascular cognitive impairment

Abstract Introduction The pathogenesis of vascular cognitive impairment (VCI) is not fully understood. GPR39, an orphan G‐protein coupled receptor, is implicated in neurological disorders but its role in VCI is unknown. Methods We performed GPR39 immunohistochemical analysis in post mortem brain sam...

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Bibliographic Details
Main Authors: Catherine M. Davis, Thierno M. Bah, Wenri H. Zhang, Jonathan W. Nelson, Kirsti Golgotiu, Xiao Nie, Farah N. Alkayed, Jennifer M. Young, Randy L. Woltjer, Lisa C. Silbert, Marjorie R. Grafe, Nabil J. Alkayed
Format: Article
Language:English
Published: Wiley 2021-01-01
Series:Alzheimer’s & Dementia: Translational Research & Clinical Interventions
Subjects:
GPR39
microglia
mild cognitive impairment
polymorphism
vascular cognitive impairment
white matter hyperintensity
Online Access:https://doi.org/10.1002/trc2.12214

Internet

https://doi.org/10.1002/trc2.12214

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