Circulating microbial products and acute phase proteins as markers of pathogenesis in lymphatic filarial disease.
Lymphatic filariasis can be associated with development of serious pathology in the form of lymphedema, hydrocele, and elephantiasis in a subset of infected patients. Dysregulated host inflammatory responses leading to systemic immune activation are thought to play a central role in filarial disease...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS Pathogens |
| Online Access: | http://europepmc.org/articles/PMC3369944?pdf=render |
| _version_ | 1818291285687009280 |
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| author | R Anuradha P Jovvian George N Pavan Kumar Michael P Fay V Kumaraswami Thomas B Nutman Subash Babu |
| author_facet | R Anuradha P Jovvian George N Pavan Kumar Michael P Fay V Kumaraswami Thomas B Nutman Subash Babu |
| author_sort | R Anuradha |
| collection | DOAJ |
| description | Lymphatic filariasis can be associated with development of serious pathology in the form of lymphedema, hydrocele, and elephantiasis in a subset of infected patients. Dysregulated host inflammatory responses leading to systemic immune activation are thought to play a central role in filarial disease pathogenesis. We measured the plasma levels of microbial translocation markers, acute phase proteins, and inflammatory cytokines in individuals with chronic filarial pathology with (CP Ag+) or without (CP Ag-) active infection; with clinically asymptomatic infections (INF); and in those without infection (endemic normal [EN]). Comparisons between the two actively infected groups (CP Ag+ compared to INF) and those without active infection (CP Ag- compared to EN) were used preliminarily to identify markers of pathogenesis. Thereafter, we tested for group effects among all the four groups using linear models on the log transformed responses of the markers. Our data suggest that circulating levels of microbial translocation products (lipopolysaccharide and LPS-binding protein), acute phase proteins (haptoglobin and serum amyloid protein-A), and inflammatory cytokines (IL-1β, IL-12, and TNF-α) are associated with pathogenesis of disease in lymphatic filarial infection and implicate an important role for circulating microbial products and acute phase proteins. |
| first_indexed | 2024-12-13T02:41:38Z |
| format | Article |
| id | doaj.art-4d557dea9b5f465787badb5ccac16902 |
| institution | Directory Open Access Journal |
| issn | 1553-7366 1553-7374 |
| language | English |
| last_indexed | 2024-12-13T02:41:38Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Pathogens |
| spelling | doaj.art-4d557dea9b5f465787badb5ccac169022022-12-22T00:02:17ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742012-01-0186e100274910.1371/journal.ppat.1002749Circulating microbial products and acute phase proteins as markers of pathogenesis in lymphatic filarial disease.R AnuradhaP Jovvian GeorgeN Pavan KumarMichael P FayV KumaraswamiThomas B NutmanSubash BabuLymphatic filariasis can be associated with development of serious pathology in the form of lymphedema, hydrocele, and elephantiasis in a subset of infected patients. Dysregulated host inflammatory responses leading to systemic immune activation are thought to play a central role in filarial disease pathogenesis. We measured the plasma levels of microbial translocation markers, acute phase proteins, and inflammatory cytokines in individuals with chronic filarial pathology with (CP Ag+) or without (CP Ag-) active infection; with clinically asymptomatic infections (INF); and in those without infection (endemic normal [EN]). Comparisons between the two actively infected groups (CP Ag+ compared to INF) and those without active infection (CP Ag- compared to EN) were used preliminarily to identify markers of pathogenesis. Thereafter, we tested for group effects among all the four groups using linear models on the log transformed responses of the markers. Our data suggest that circulating levels of microbial translocation products (lipopolysaccharide and LPS-binding protein), acute phase proteins (haptoglobin and serum amyloid protein-A), and inflammatory cytokines (IL-1β, IL-12, and TNF-α) are associated with pathogenesis of disease in lymphatic filarial infection and implicate an important role for circulating microbial products and acute phase proteins.http://europepmc.org/articles/PMC3369944?pdf=render |
| spellingShingle | R Anuradha P Jovvian George N Pavan Kumar Michael P Fay V Kumaraswami Thomas B Nutman Subash Babu Circulating microbial products and acute phase proteins as markers of pathogenesis in lymphatic filarial disease. PLoS Pathogens |
| title | Circulating microbial products and acute phase proteins as markers of pathogenesis in lymphatic filarial disease. |
| title_full | Circulating microbial products and acute phase proteins as markers of pathogenesis in lymphatic filarial disease. |
| title_fullStr | Circulating microbial products and acute phase proteins as markers of pathogenesis in lymphatic filarial disease. |
| title_full_unstemmed | Circulating microbial products and acute phase proteins as markers of pathogenesis in lymphatic filarial disease. |
| title_short | Circulating microbial products and acute phase proteins as markers of pathogenesis in lymphatic filarial disease. |
| title_sort | circulating microbial products and acute phase proteins as markers of pathogenesis in lymphatic filarial disease |
| url | http://europepmc.org/articles/PMC3369944?pdf=render |
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