Assessing the Cntnap2 knockout rat prepulse inhibition deficit through prepulse scaling of the baseline startle response curve

Abstract Many neurodevelopmental disorders, including autism spectrum disorder (ASD), are associated with changes in sensory processing and sensorimotor gating. The acoustic startle response and prepulse inhibition (PPI) of startle are widely used translational measures for assessing sensory process...

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Bibliographic Details
Main Authors: Alaa El-Cheikh Mohamad, Dorit Möhrle, Faraj L. Haddad, Anton Rose, Brian L. Allman, Susanne Schmid
Format: Article
Language:English
Published: Nature Publishing Group 2023-10-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-023-02629-6