Differential modulation of NMDA and AMPA receptors by cellular prion protein and copper ions

Differential modulation of NMDA and AMPA receptors by cellular prion protein and copper ions

Abstract N-Methyl-D-aspartate receptors (NMDARs) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) are two major types of ionotropic glutamate receptors involved in synaptic transmission. However, excessive activity of these receptors can be cytotoxic and thus their functio...

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Bibliographic Details
Main Authors: Sun Huang, Lina Chen, Chris Bladen, Peter K. Stys, Gerald W. Zamponi
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Molecular Brain
Subjects:
NMDA receptor
AMPA receptor
Cellular prion protein
Knock-in mice
Whole-cell patch clamp
Hippocampal neurons
Online Access:http://link.springer.com/article/10.1186/s13041-018-0406-3

Internet

http://link.springer.com/article/10.1186/s13041-018-0406-3

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