Cumulative risks of colorectal cancer in Han Chinese patients with Lynch syndrome in Taiwan
Abstract Patients with Lynch syndrome have a high risk of colorectal cancer (CRC). In this study, we estimated the age- and sex-specific cumulative risks of CRC in Han Chinese patients with Lynch syndrome caused by the pathogenic germline mutations in MLH1 or MSH2 in Taiwan. Based on 321 mutation ca...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-04-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-88289-2 |
| _version_ | 1818851670581313536 |
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| author | Abram Bunya Kamiza Wen-Chang Wang Jeng-Fu You Reiping Tang Huei-Tzu Chien Chih-Hsiung Lai Li-Ling Chiu Tsai-Ping Lo Kuan-Yi Hung Chao A. Hsiung Chih-Ching Yeh |
| author_facet | Abram Bunya Kamiza Wen-Chang Wang Jeng-Fu You Reiping Tang Huei-Tzu Chien Chih-Hsiung Lai Li-Ling Chiu Tsai-Ping Lo Kuan-Yi Hung Chao A. Hsiung Chih-Ching Yeh |
| author_sort | Abram Bunya Kamiza |
| collection | DOAJ |
| description | Abstract Patients with Lynch syndrome have a high risk of colorectal cancer (CRC). In this study, we estimated the age- and sex-specific cumulative risks of CRC in Han Chinese patients with Lynch syndrome caused by the pathogenic germline mutations in MLH1 or MSH2 in Taiwan. Based on 321 mutation carriers and 419 non-mutation carriers from 75 pedigrees collected in an Amsterdam criteria family registry in Taiwan, the age- and sex-specific cumulative risks of CRC in male carriers of mutation in MLH1 and MSH2 at the age of 70 years were 60.3% (95% confidence interval (CI) = 31.1%–89.9%) and 76.7% (95% CI = 37.2%–99.0%), respectively. For females, the cumulative risks of CRC at the age of 70 were estimated to be 30.6% (95% CI = 14.3%–57.7%) and 49.3% (95% CI = 21.9%–84.5%) in the carriers of MLH1 and MSH2 germline mutations, respectively. In conclusion, the cumulative risks of CRC at the age of 70 in the Han Chinese patients is higher in mutation carriers than non-mutation carriers and male mutation carriers have a higher cumulative risk of developing CRC than the female mutation carriers. |
| first_indexed | 2024-12-19T07:08:43Z |
| format | Article |
| id | doaj.art-4d5c960d35bb4e03a866c9c43b2d7bfd |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-19T07:08:43Z |
| publishDate | 2021-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-4d5c960d35bb4e03a866c9c43b2d7bfd2022-12-21T20:31:13ZengNature PortfolioScientific Reports2045-23222021-04-011111810.1038/s41598-021-88289-2Cumulative risks of colorectal cancer in Han Chinese patients with Lynch syndrome in TaiwanAbram Bunya Kamiza0Wen-Chang Wang1Jeng-Fu You2Reiping Tang3Huei-Tzu Chien4Chih-Hsiung Lai5Li-Ling Chiu6Tsai-Ping Lo7Kuan-Yi Hung8Chao A. Hsiung9Chih-Ching Yeh10School of Public Health, College of Public Health, Taipei Medical UniversityThe Ph.D. Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical UniversityColorectal Section, Department of Surgery, Chang Gung Memorial HospitalColorectal Section, Department of Surgery, Chang Gung Memorial HospitalDepartment of Nutrition and Health Sciences, Chang Gung University of Science and TechnologyDepartment of Public Health, College of Medicine, Chang Gung UniversityDepartment of Nutrition and Health Sciences, Chang Gung University of Science and TechnologyInstitute of Population Health Sciences, National Health Research InstitutesInstitute of Population Health Sciences, National Health Research InstitutesInstitute of Population Health Sciences, National Health Research InstitutesSchool of Public Health, College of Public Health, Taipei Medical UniversityAbstract Patients with Lynch syndrome have a high risk of colorectal cancer (CRC). In this study, we estimated the age- and sex-specific cumulative risks of CRC in Han Chinese patients with Lynch syndrome caused by the pathogenic germline mutations in MLH1 or MSH2 in Taiwan. Based on 321 mutation carriers and 419 non-mutation carriers from 75 pedigrees collected in an Amsterdam criteria family registry in Taiwan, the age- and sex-specific cumulative risks of CRC in male carriers of mutation in MLH1 and MSH2 at the age of 70 years were 60.3% (95% confidence interval (CI) = 31.1%–89.9%) and 76.7% (95% CI = 37.2%–99.0%), respectively. For females, the cumulative risks of CRC at the age of 70 were estimated to be 30.6% (95% CI = 14.3%–57.7%) and 49.3% (95% CI = 21.9%–84.5%) in the carriers of MLH1 and MSH2 germline mutations, respectively. In conclusion, the cumulative risks of CRC at the age of 70 in the Han Chinese patients is higher in mutation carriers than non-mutation carriers and male mutation carriers have a higher cumulative risk of developing CRC than the female mutation carriers.https://doi.org/10.1038/s41598-021-88289-2 |
| spellingShingle | Abram Bunya Kamiza Wen-Chang Wang Jeng-Fu You Reiping Tang Huei-Tzu Chien Chih-Hsiung Lai Li-Ling Chiu Tsai-Ping Lo Kuan-Yi Hung Chao A. Hsiung Chih-Ching Yeh Cumulative risks of colorectal cancer in Han Chinese patients with Lynch syndrome in Taiwan Scientific Reports |
| title | Cumulative risks of colorectal cancer in Han Chinese patients with Lynch syndrome in Taiwan |
| title_full | Cumulative risks of colorectal cancer in Han Chinese patients with Lynch syndrome in Taiwan |
| title_fullStr | Cumulative risks of colorectal cancer in Han Chinese patients with Lynch syndrome in Taiwan |
| title_full_unstemmed | Cumulative risks of colorectal cancer in Han Chinese patients with Lynch syndrome in Taiwan |
| title_short | Cumulative risks of colorectal cancer in Han Chinese patients with Lynch syndrome in Taiwan |
| title_sort | cumulative risks of colorectal cancer in han chinese patients with lynch syndrome in taiwan |
| url | https://doi.org/10.1038/s41598-021-88289-2 |
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