Comparative in vitro treatment of mesenchymal stromal cells with GDF‐5 and R57A induces chondrogenic differentiation while limiting chondrogenic hypertrophy

Comparative in vitro treatment of mesenchymal stromal cells with GDF‐5 and R57A induces chondrogenic differentiation while limiting chondrogenic hypertrophy

Abstract Purpose Hypertrophic cartilage is an important characteristic of osteoarthritis and can often be found in patients suffering from osteoarthritis. Although the exact pathomechanism remains poorly understood, hypertrophic de‐differentiation of chondrocytes also poses a major challenge in the...

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Bibliographic Details
Main Authors: Manuel Weißenberger, Mike Wagenbrenner, Joachim Nickel, Rasmus Ahlbrecht, Torsten Blunk, Andre F. Steinert, Fabian Gilbert
Format: Article
Language:English
Published: Wiley 2023-01-01
Series:Journal of Experimental Orthopaedics
Subjects:
Bone marrow
Cartilage
Chondrogenesis
Chondrogenic hypertrophy
Mesenchymal stromal cell
GDF‐5
Online Access:https://doi.org/10.1186/s40634-023-00594-z

Internet

https://doi.org/10.1186/s40634-023-00594-z

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