Ligation of free HMGB1 to TLR2 in the absence of ligand is negatively regulated by the C-terminal tail domain

Ligation of free HMGB1 to TLR2 in the absence of ligand is negatively regulated by the C-terminal tail domain

Abstract Background High mobility group box 1 (HMGB1) protein is a central endogenous inflammatory mediator contributing to the pathogenesis of several inflammatory disorders. HMGB1 interacts with toll-like receptors (TLRs) but contradictory evidence regarding its identity as a TLR2 ligand persists....

Full description

Bibliographic Details
Main Authors: Hannah Aucott, Agnieszka Sowinska, Helena Erlandsson Harris, Peter Lundback
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Molecular Medicine
Subjects:
HMGB1
TLR2
Alarmin
Receptor
Protein-protein interactions
Inflammation
Online Access:http://link.springer.com/article/10.1186/s10020-018-0021-x

Internet

http://link.springer.com/article/10.1186/s10020-018-0021-x

Similar Items