Association of thymidylate synthase gene 3'-untranslated region polymorphism with sensitivity of non-small cell lung cancer to pemetrexed treatment: TS gene polymorphism and pemetrexed sensitivity in NSCLC

Association of thymidylate synthase gene 3'-untranslated region polymorphism with sensitivity of non-small cell lung cancer to pemetrexed treatment: TS gene polymorphism and pemetrexed sensitivity in NSCLC

<p>Abstract</p> <p>Background</p> <p>Thymidylate synthase (TS) is a key enzyme responsible for DNA synthesis and repair. Altered expression of TS protein or <it>TS</it> gene polymorphisms has been associated with cancer progression and treatment response. Th...

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Bibliographic Details
Main Authors: Wang Xia, Wang Yadi, Wang Yue, Cheng Jian, Wang Yanyun, Ha Minwen
Format: Article
Language:English
Published: BMC 2013-01-01
Series:Journal of Biomedical Science
Subjects:
Lung adenocarcinoma
Non-small cell lung cancer
Pemetrexed treatment
Thymidylate synthase
<it>TS</it> gene polymorphism
Online Access:http://www.jbiomedsci.com/content/20/1/5

Internet

http://www.jbiomedsci.com/content/20/1/5

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