Molecular Mechanism of Zinc-Dependent Oligomerization of Alzheimer’s Amyloid-β with Taiwan (D7H) Mutation

Molecular Mechanism of Zinc-Dependent Oligomerization of Alzheimer’s Amyloid-β with Taiwan (D7H) Mutation

Amyloid-β (Aβ) is a peptide formed by 39–43 amino acids, heterogenous by the length of its C-terminus. Aβ constitutes a subnanomolar monomeric component of human biological fluids; however, in sporadic variants of Alzheimer’s disease (AD), it forms soluble neurotoxic oligomers and accumulates as ins...

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Bibliographic Details
Main Authors: Olga I. Kechko, Alexei A. Adzhubei, Anna P. Tolstova, Maria I. Indeykina, Igor A. Popov, Sergey S. Zhokhov, Nikolay V. Gnuchev, Vladimir A. Mitkevich, Alexander A. Makarov, Sergey A. Kozin
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:International Journal of Molecular Sciences
Subjects:
Alzheimer’s disease
amyloid-beta
familial Taiwan mutation D7H
zinc
metal binding domain
oligomerization
Online Access:https://www.mdpi.com/1422-0067/24/14/11241

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https://www.mdpi.com/1422-0067/24/14/11241

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