Perforin-2 is essential for intracellular defense of parenchymal cells and phagocytes against pathogenic bacteria

Perforin-2 is essential for intracellular defense of parenchymal cells and phagocytes against pathogenic bacteria

Perforin-2 (MPEG1) is a pore-forming, antibacterial protein with broad-spectrum activity. Perforin-2 is expressed constitutively in phagocytes and inducibly in parenchymal, tissue-forming cells. In vitro, Perforin-2 prevents the intracellular replication and proliferation of bacterial pathogens in t...

Full description

Bibliographic Details
Main Authors: Ryan M McCormack, Lesley R de Armas, Motoaki Shiratsuchi, Desiree G Fiorentino, Melissa L Olsson, Mathias G Lichtenheld, Alejo Morales, Kirill Lyapichev, Louis E Gonzalez, Natasa Strbo, Neelima Sukumar, Olivera Stojadinovic, Gregory V Plano, George P Munson, Marjana Tomic-Canic, Robert S Kirsner, David G Russell, Eckhard R Podack
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-09-01
Series:eLife
Subjects:
MRSA
ROS
NO
S. typhimurium
Mycobacterium tuberculosis
pathogenic bacteria
Online Access:https://elifesciences.org/articles/06508

Internet

https://elifesciences.org/articles/06508

Similar Items