Clusterin Deficiency Exacerbates Hyperoxia-Induced Acute Lung Injury

Clusterin Deficiency Exacerbates Hyperoxia-Induced Acute Lung Injury

Exposure to high oxygen concentrations leads to generation of excessive reactive oxygen species, causing cellular injury and multiple organ dysfunctions and is associated with a high mortality rate. Clusterin (CLU) is a heterodimeric glycoprotein that mediates several intracellular signaling pathway...

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Bibliographic Details
Main Authors: Jung Yeon Hong, Mi Na Kim, Eun Gyul Kim, Jae Woo Lee, Hye Rin Kim, Soo Yeon Kim, Soon Min Lee, Yoon Hee Kim, Kyung Won Kim, Myung Hyun Sohn
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cells
Subjects:
clusterin
acute lung injury
hyperoxia
apoptosis
inflammation
Online Access:https://www.mdpi.com/2073-4409/10/4/944

Internet

https://www.mdpi.com/2073-4409/10/4/944

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