Age-Related Dysfunction in Mechanotransduction Impairs Differentiation of Human Mammary Epithelial Progenitors

Age-Related Dysfunction in Mechanotransduction Impairs Differentiation of Human Mammary Epithelial Progenitors

Dysfunctional progenitor and luminal cells with acquired basal cell properties accumulate during human mammary epithelial aging for reasons not understood. Multipotent progenitors from women aged <30 years were exposed to a physiologically relevant range of matrix elastic modulus (stiffness). Inc...

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Bibliographic Details
Main Authors: Fanny A. Pelissier, James C. Garbe, Badriprasad Ananthanarayanan, Masaru Miyano, ChunHan Lin, Tiina Jokela, Sanjay Kumar, Martha R. Stampfer, James B. Lorens, Mark A. LaBarge
Format: Article
Language:English
Published: Elsevier 2014-06-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714003969

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http://www.sciencedirect.com/science/article/pii/S2211124714003969

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