Single cell profiling of female breast fibroadenoma reveals distinct epithelial cell compositions and therapeutic targets

Abstract Fibroadenomas (FAs) are the most common breast tumors in women. No pharmacological agents are currently approved for FA intervention owing to its unclear mechanisms and a shortage of reproducible human models. Here, using single-cell RNA sequencing of human FAs and normal breast tissues, we...

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Bibliographic Details
Main Authors: Zhigang Chen, Yi Zhang, Wenlu Li, Chenyi Gao, Fengbo Huang, Lu Cheng, Menglei Jin, Xiaoming Xu, Jian Huang
Format: Article
Language:English
Published: Nature Portfolio 2023-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-39059-3