A small-molecule degrader selectively inhibits the growth of ALK-rearranged lung cancer with ceritinib resistance

A small-molecule degrader selectively inhibits the growth of ALK-rearranged lung cancer with ceritinib resistance

Summary: Anaplastic lymphoma kinase (ALK) is a highly responsive therapeutic target for ALK-rearranged non-small cell lung cancer (NSCLC). However, patients with this cancer invariably relapse because of the development of ALK inhibitor resistance resulting from mutations within the ALK tyrosine kin...

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Bibliographic Details
Main Authors: Xin Li, Zixiong Wang, Chao Chen, Fan Yang, Ping Liu, Shu Fang, Bin Wang, Shi Chen, Xinjian Li
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:iScience
Subjects:
Pharmacology
Natural sciences
Biological sciences
Biochemistry
Cell biology
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224002360

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http://www.sciencedirect.com/science/article/pii/S2589004224002360

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