Atherosclerotic plaque development in mice is enhanced by myeloid ZEB1 downregulation

Atherosclerotic plaque development in mice is enhanced by myeloid ZEB1 downregulation

Abstract Accumulation of lipid-laden macrophages within the arterial neointima is a critical step in atherosclerotic plaque formation. Here, we show that reduced levels of the cellular plasticity factor ZEB1 in macrophages increase atherosclerotic plaque formation and the chance of cardiovascular ev...

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Bibliographic Details
Main Authors: M. C. Martinez-Campanario, Marlies Cortés, Alazne Moreno-Lanceta, Lu Han, Chiara Ninfali, Verónica Domínguez, María J. Andrés-Manzano, Marta Farràs, Anna Esteve-Codina, Carlos Enrich, Francisco J. Díaz-Crespo, Belén Pintado, Joan C. Escolà-Gil, Pablo García de Frutos, Vicente Andrés, Pedro Melgar-Lesmes, Antonio Postigo
Format: Article
Language:English
Published: Nature Portfolio 2023-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-43896-7

Internet

https://doi.org/10.1038/s41467-023-43896-7

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