Screening for Optimal Liposome Preparation Conditions by Using Dual Centrifugation and Time-Resolved Fluorescence Measurements

Screening for Optimal Liposome Preparation Conditions by Using Dual Centrifugation and Time-Resolved Fluorescence Measurements

Dual centrifugation (DC) is a novel in-vial homogenization technique for the preparation of liposomes in small batch sizes under gentle and sterile conditions which allows encapsulation efficiencies (<i>EE</i>) for water soluble compounds of >50%. Since liposome size, size distributio...

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Bibliographic Details
Main Authors: Jonas K. Koehler, Johannes Schnur, Heiko Heerklotz, Ulrich Massing
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Pharmaceutics
Subjects:
dual centrifugation
liposomes
vesicular phospholipid gel
encapsulation efficiency
time-resolved fluorescence
differential scanning calorimetry
Online Access:https://www.mdpi.com/1999-4923/13/12/2046

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https://www.mdpi.com/1999-4923/13/12/2046

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