ACE2 decoy receptor generated by high-throughput saturation mutagenesis efficiently neutralizes SARS-CoV-2 and its prevalent variants

ACE2 decoy receptor generated by high-throughput saturation mutagenesis efficiently neutralizes SARS-CoV-2 and its prevalent variants

The recent global pandemic was a spillover from the SARS-CoV-2 virus. Viral entry involves the receptor binding domain (RBD) of the viral spike protein interacting with the protease domain (PD) of the cellular receptor, ACE2. We hereby present a comprehensive mutational landscape of the effects of A...

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Bibliographic Details
Main Authors: Bolun Wang, Junxuan Zhao, Shuo Liu, Jingyuan Feng, Yufeng Luo, Xinyu He, Yanmin Wang, Feixiang Ge, Junyi Wang, Buqing Ye, Weijin Huang, Xiaochen Bo, Youchun Wang, Jianzhong Jeff Xi
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Emerging Microbes and Infections
Subjects:
SARS-CoV-2
ACE2
high-throughput screening
protein engineering
decoy receptor
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2022.2079426

Internet

https://www.tandfonline.com/doi/10.1080/22221751.2022.2079426

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