Evaluation of the inhibitory effect of azoles on pharmacokinetics of lenvatinib in rats both in vivo and in vitro by UPLC‐MS/MS

Evaluation of the inhibitory effect of azoles on pharmacokinetics of lenvatinib in rats both in vivo and in vitro by UPLC‐MS/MS

Abstract Background Lenvatinib is a multitargeted tyrosine kinase inhibitor used in the treatment of a variety of solid tumors. This study aims to investigate the potential pharmacokinetic interactions between lenvatinib and various azoles (ketoconazole, voriconazole, isavuconazole and posaconazole)...

Full description

Bibliographic Details
Main Authors: Mengming Xia, Xueyi Song, Zebei Lu, Yu Wang, Quan Zhou, Peiwu Geng, Shuanghu Wang, Yunfang Zhou, Qingjun Wu, Aixia Han
Format: Article
Language:English
Published: Wiley 2023-11-01
Series:Thoracic Cancer
Subjects:
azoles
CYP3A4
drug‐drug interactions
lenvatinib
pharmacokinetic
Online Access:https://doi.org/10.1111/1759-7714.15125

Internet

https://doi.org/10.1111/1759-7714.15125

Similar Items