The RNA Methyltransferase METTL3 Promotes Endothelial Progenitor Cell Angiogenesis in Mandibular Distraction Osteogenesis via the PI3K/AKT Pathway

The RNA Methyltransferase METTL3 Promotes Endothelial Progenitor Cell Angiogenesis in Mandibular Distraction Osteogenesis via the PI3K/AKT Pathway

Distraction osteogenesis (DO) is used to treat large bone defects in the field of oral and maxillofacial surgery. Successful DO-mediated bone regeneration is dependent upon angiogenesis, and endothelial progenitor cells (EPCs) are key mediators of angiogenic processes. The N6-methyladenosine (m6A) m...

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Bibliographic Details
Main Authors: Weidong Jiang, Peiqi Zhu, Fangfang Huang, Zhenchen Zhao, Tao Zhang, Xiaoning An, Fengchun Liao, Lina Guo, Yan Liu, Nuo Zhou, Xuanping Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
distraction osteogenesis
METTL3
angiogenesis
PI3K/AKT signaling pathway
endothelial progenitor cells
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.720925/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.720925/full

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