Design, Synthesis, In Vitro and In Silico Studies of New Thiazolylhydrazine-Piperazine Derivatives as Selective MAO-A Inhibitors

Design, Synthesis, In Vitro and In Silico Studies of New Thiazolylhydrazine-Piperazine Derivatives as Selective MAO-A Inhibitors

Monoamine oxidase (MAO) isoenzymes are very important drug targets among neurological disorders. Herein, novel series of thiazolylhydrazine-piperazine derivatives were designed, synthesized and evaluated for their MAO-A and -B inhibitory activity. The structures of the synthesized compounds were ass...

Full description

Bibliographic Details
Main Authors: Begüm Nurpelin Sağlık, Osman Cebeci, Ulviye Acar Çevik, Derya Osmaniye, Serkan Levent, Betül Kaya Çavuşoğlu, Sinem Ilgın, Yusuf Özkay, Zafer Asım Kaplancıklı
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Molecules
Subjects:
ADME properties
in vitro enzyme inhibition
molecular docking
monoamine oxidases
thiazolylhydrazine
piperazine
Online Access:https://www.mdpi.com/1420-3049/25/18/4342

Internet

https://www.mdpi.com/1420-3049/25/18/4342

Similar Items