The Role of VCP Mutations in the Spectrum of Amyotrophic Lateral Sclerosis—Frontotemporal Dementia

The Role of VCP Mutations in the Spectrum of Amyotrophic Lateral Sclerosis—Frontotemporal Dementia

Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD) are two neurological diseases which, respectively, and primarily affect motor neurons and frontotemporal lobes. Although they can lead to different signs and symptoms, it is now evident that these two pathologies form a continuum...

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Bibliographic Details
Main Authors: Eveljn Scarian, Giuseppe Fiamingo, Luca Diamanti, Ilaria Palmieri, Stella Gagliardi, Orietta Pansarasa
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Neurology
Subjects:
ALS
FTD
VCP
protein clearance
autophagy
lysophagy
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2022.841394/full

Internet

https://www.frontiersin.org/articles/10.3389/fneur.2022.841394/full

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